5 edition of Toxin-induced models of neurological disorders found in the catalog.
Includes bibliographical references and index.
|Statement||edited by Michael L. Woodruff and Arthur J. Nonneman.|
|Contributions||Woodruff, Michael L., Nonneman, Arthur J.|
|LC Classifications||RC347.5 .T69 1994|
|The Physical Object|
|Pagination||xxi, 344 p. :|
|Number of Pages||344|
|LC Control Number||94009808|
Request PDF | Animal Models of Neurological Disorders | Of primary concern to an investigator of neurological disorders is that of the selection of the most relevant animal model to achieve his or. Occupational therapists must be able to fully consider the physical, cognitive, emotional, psychological and behavioural problems which may occur as a consequence of a neurological disorder, and understand the impact of diagnosis from a person-centred perspective.
This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes Format: Hardcover. The book carefully links structure and function—and behavioral and biological science—for a more nuanced understanding of brain development and of pathologies as varied as pervasive developmental disorders, learning disabilities, neuromotor dysfunction, seizure disorders, and childhood cancers.
Animal Models of Neurological Disease, II Metabolic Encephalopathies and the Epilepsies NEUROMETHODS 0 22 Edited by Alan A. Boulton University of Saskatchewan, Saskatoon, Canada Glen B. Baker University of Alberta, Edmonton, Canada and Roger F. Butterworth University of Montreal, Montreal, Canada Humana Press l Totowa,NewJersey. Aims & Scope. CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.
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Tbe models presented use neuro toxins to induce some or most of the pathophysiological changes (including behavioral) that characterize the most studied motor neuron disorders and cogni tive disorders (dementia) in humans.
Within the biomedical research community, there is little doubt about the utility of such models. Buy Toxin-Induced Models of Neurological Disorders by Arthur J. Nonneman, Michael L. Woodruff from Waterstones today. Click and Collect from your local Waterstones. Toxin-induced models of neurological disorders.
New York: Plenum Press, © (OCoLC) Online version: Toxin-induced models of neurological disorders. New York: Plenum Press, © (OCoLC) Material Type: Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: Michael L Woodruff; Arthur J Nonneman.
Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by : Roger Barker.
This is followed by a chapter on strategies for developing neurotoxicant-induced animal models of neurodegenerative disorders.
Chapters on motor neuron degeneration, chapters on different models of Parkinson's disease, Huntington's disease Author: Robert M. Herndon. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by page.
Whereas recent genetic discoveries have lead to a number of different genetic models of PD, none of these shows the typical degeneration of dopaminergic neurons. Thus far, among the various accepted experimental models of PD, neurotoxins have remained the most popular tools to produce selective neuronal death in both in vitro and in vivo systems.
Abstract. Several pieces of evidence suggest a relationship between environmental toxin exposure and onset of neurodegenerative diseases. Epidemiological evidence strongly supports the hypothesis that environmental agents cause neurological diseases, but specific chemicals that produce neurodegenerative diseases have not been identified.
1,2 The concern about environmental toxins. Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders.
Toxin-Induced Models of Parkinson's Disease Jordi Bové, Delphine Prou, Céline Perier, and Serge Przedborski Departments of Neurology and Pathology, and the Center for Neurobiology and Behavior, Columbia University, New York, New York The Use of the R6 Transgenic Mouse Models of Huntington's Disease in Attempts to Develop Novel Therapeutic Strategies Jia Yi Li, Natalija Popovic, Patrik Brundin Pages Neurological disorders: a public health approach 41 Dementia 42 Epilepsy 56 Headache disorders 70 Multiple sclerosis 85 Neuroinfections 95 Neurological disorders associated with malnutrition Pain associated with neurological disorders.
This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures.
Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins. Occupational Neurology. a volume in the Handbook of Clinical Neurology Series, provides a comprehensive overview of the science, clinical diagnosis, and treatment for neurotoxin related neurological and psychiatric disorders.
This timely collection provides not only a complete scientific reference on the chemical origin of this class of neurological and psychiatric disorders, but also a. These models aim to reproduce key pathogenic features of PD including movement disorder induced by progressive loss of dopaminergic neurons in the substantia nigra and the formation of α-synuclein containing Lewy body inclusions.
Experimental PD models can be divided in toxin-induced models and genetic models. Toxin-induced PD models. Scopolamine, a Toxin-Induced Experimental Model, Used for Research in Alzheimer’s Disease it is often used to induce cognitive disorders in experimental models as it readily permeates the bloodbrain barrier.
In the context of Alzheimer’s disease, its effects include causing cholinergic dysfunction and increasing amyloid-β deposition. Furthermore, SRY expression is dysregulated in a toxin-induced model of PD, suggesting a role for SRY in the pathogenesis of dopamine cells. Taken together, these studies highlight the importance of understanding the interplay between sex-specific hormones and sex-specific genes in healthy and diseased brain.
In particular, better understanding of regulation and function of SRY in the male brain. CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.
Hence, development of suitable animal models is essential to the drug discovery and development process so that new molecules are obtained that helps to overcome dementia and other memory disorders .In addition, appropriate animal models of neurodegenerative conditions are precious to understand the pathophysiology of dementia and development of new therapeutics [14,15].
toxin-induced cognitive impairment in various experimental models. Based on their target toxicity of these toxins we would also discuss how these models can be used to investigate potential nootropic. Chemically Induced Models of Epilepsy, In Animal Models of Neurological Disease, II, Metabolic Encephalopathies and the Epilepsy's Chapter (PDF Available) February with 42 Reads How we.This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures.
Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes.
Scopolamine-Induced Memory Impairment. The significance of cholinergic action in the brain for learning and memory functions was first recognized more than three decades ago, when comparatively low doses of certain muscarinic acetylcholine receptor antagonists (e.g., the belladonna alkaloids scopolamine and atropine) were established to induce temporary cognitive deficits in young .